Aims & Objective– To study the distribution of Klebsiella pneumonia isolates from various clinical samples and its antibiotic susceptibility pattern in patients attending a tertiary care hospital. Material & Method– Samples received in Microbiology department for Culture & sensitivity were processed and identified using biochemical tests, antibiotic susceptibility test was done to assess resistance pattern to various antibiotics. Results– Out of 3254 samples received for culture & sensitivity between April 2018 to August 2018, growth was seen in 1291 (39.67%) samples. Out of which 134 (10.45%) samples showed growth of Klebsiella. Males 71 (52.98%) were more commonly affected by infections caused by Klebsiella then females 67 (50.0%). Most common age group affected was between 15 –45 years, maximum growth of Klebsiella was noted in IPD patients especially from Surgery department. Klebsiella (n=134) was most commonly isolated from wound swab 40(29.90%), followed by urine sample 32 (24.0%) and pus 23 (17.20%). Klebsiella isolates showed higher sensitivity to piperacillin–tazobactam, amikacin , imipenem, and fluroquinolones. Maximum resistance was noted for ampicillin and  ceftriaxone. About 47 (35.0%) of Klebsiella isolates were ESBL producers while 27 (20.0%) of Klebsiella isolates were MBL producers.