Haematometra and hematocolpos secondary to congenital vaginal obstruction has been commonly reported in literature, especially at the onset of puberty. But presentation of neonatal or congenital pyometra and pyocolpos is uncommon and unclear about its origin. The grossly distended genital tract may cause pressure symptoms on urinary obstruction and the enlargement of the bladder may hinder palpation of the vaginal cyst. Pyuria will be a further complication in cases of secondary hydroureter and hydroneprosis due to pyometra. Posterior pressure may also cause rectal obstruction. In this communication we present our experience with three cases of neonatal pyometrocolpos along with review of the pertinent literature.