INTRODUCTION: To improve the survival after a cardiac–arrest the key is the quality of emergency care in the hospitals. Early CPR, early fibrillation, early transfer to specialist care of offering the best post–resuscitation care can bring out a best outcome in a witnessed cardiac–arrest. Improving the outcome of patients who survive cardiac–arrest requires stopping the ischemic process as quickly as possible and preventing damage from reperfusion. Therapeutic hypothermia decreases the metabolic rate by 6% to 7% for every decrease of 1°C in temperature. METHOD: The research design selected for this study was pre–experimental one group pre and post–test research design. Non probability Purposive sampling techniques was adopted to select 60 samples for the study. In the present study structured knowledge questionnaire was used to assess the knowledge of staff nurses on effect of therapeutic hypothermia in post cardiac arrest patients. RESULTS: Study revealed that ,there was a significant difference between the post test knowledge score of staff nurses on effect of therapeutic hypothermia in post cardiac arrest patients. Since the calculated t value (t=30.706) was significantly higher than table value(t=2.661) at 0.05 level of significance. CONCLUSION: The findings of the study showed that educational programme was effective in increasing knowledge of staff nurses regarding effect of therapeutic hypothermia in post cardiac arrest patients.