Background: It is very essential to have a good knowledge about hepatic arterial anatomical variations while performing hepatopancreaticobiliary surgical procedures. The frequency of inadvertent or iatrogenic hepatic vascular injury rises in the event of aberrant anatomy and variations. Our study emphasizes the variations of hepatic artery especially the replaced right hepatic artery while doing pancreatico duodenectomy. Methods: During routine 50 hepatopancreatico biliary surgeries done from the period of 2013 to 2018 at department of surgical gastro enterology i n kanyakumari government medical college, asaripallam,tamil nadu. We came across 2 cases of variations of right hepatic artery which was picked up and studied. Results: Out of 50 hepatopancreatico biliary surgeries, only 2 cases(4%) showed the presence of replacing right hepatic artery originating from superior mesenteric artery. Conclusions: An intact hepatic artery is the gateway to successful hepato biliary surgery. Surgeons undertaking hepato biliary surgery must know the hepatic artery anatomy to recognise multiple variants for safe surgery and low morbidity.